Objective
It is proposed to develop a new class of Diels-Alder reaction involving cycloaddition of electron-rich alkoxy-substituted 1, 3-dienes with alkymyl-suJlones. This kind of reaction will be investigated in both inter- and intramolecular modes.
In the first part, it is intended to apply this methodology to the synthesis of tether molecules for covalent cross-linking of oligopeptide sequences via the N-termini. It is proposed that these rigidly-oriented peptide sequences will have the requisite geometry to inhibit competitively the homodimerisation of the two domains of HIV-1 protease enzyme. It is this dimerisation which creates the enzyme active site and the catalytic activity essential for the virus replication cycle.
In the second phase of the work it is proposed also to explore the potential of the intramolecular variant of this novel pairing of diene and dienophile for the assembly of the key A-ring sub-unit of the taxol family of potent anti-cancer compounds exemplified by the parent taxol and analogues such as taxotere.
Fields of science (EuroSciVoc)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW7 2AZ LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.