Skip to main content
European Commission logo
English English
CORDIS - EU research results
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary
Content archived on 2024-05-14

The role of substance p in the developing central nervous system

Objective



The degree to which neuronal phenotype in the developing spinal cord is progressively restricted by environmental signals is poorly understood. I intend to investigate this problem by examining targeted deletions of the NK1 gene in mice. This gene has been implicated in a particular aspect of the neuronal development such as the dorsoventral patterning of the neural tube and axon guidance across the midline. Embryos will be analysed using immunochemical, in situ hybridisation and dye tracing techniques, and in vivo approaches will be complemented by in vitro analysis after pharmaco logycal manipulation using spinal cord explants in collagen gels and roller culture of postimplantation embryos.

Fields of science

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

Call for proposal

Data not available

Coordinator

University de Alicante
EU contribution
No data
Address
C.de San Vicente de Raspeig s/n
03080 Alicante
Spain

See on map

Total cost
No data

Participants (1)