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The role of substance p in the developing central nervous system

Objective



The degree to which neuronal phenotype in the developing spinal cord is progressively restricted by environmental signals is poorly understood. I intend to investigate this problem by examining targeted deletions of the NK1 gene in mice. This gene has been implicated in a particular aspect of the neuronal development such as the dorsoventral patterning of the neural tube and axon guidance across the midline. Embryos will be analysed using immunochemical, in situ hybridisation and dye tracing techniques, and in vivo approaches will be complemented by in vitro analysis after pharmaco logycal manipulation using spinal cord explants in collagen gels and roller culture of postimplantation embryos.

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

University de Alicante
Address
C.de San Vicente De Raspeig S/n
03080 Alicante
Spain

Participants (1)

Not available
Spain