Objective
The genetic mechanisms of the central nervous system (CNS) patterning occuring during early ontogenesis are still poorly understood. (i) Members of the fork head (fkh) family of genes share homology at the level of a novel DNA-binding motif coding sequence and some have been demonstrated to regulate axis formation. I propose to further study a putative new mouse member to elucidate its function in pattern formation by using gene targeting procedures. (ii) Pax-3 and Pax-6 are transcription factors expressed in the embryonic CNS under the regulation of signals controlling the neural tube polarity. Drosophila, rat, mouse and human mutant studies indicate that they are important morphoregulators. In order to study their function in CNS patterning and cell differentitation, I propose to analyse the effects of ectopic expression of the Pax-3 and Pax-6 genes in the CNS under the regulation of the En-2 and Wnt-l gene promoter/enhancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
14424 GROSS GLIENICKE POTSDAM
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.