Novel aspects of intramolecular free radical ipso substitution

Project Information

Grant agreement ID: FMBI950116

Project closed

Start date 1 April 1996

End date 31 March 1997

Funded under

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Total cost No data

EU contribution No data

Coordinated by

UNIVERSITY COLLEGE LONDON
United Kingdom

Objective

The objectives of the present programme are related to the discovery an application of novel free radical chain reactions for organic synthesis. Within the last decade, the advantages of such a strategy, which include mild neutral conditions and the ability to operate in hindered environments, have come to be appreciated. The group of Professor Motherwell has developped several such reactions in recent years (l).
Within this framework, the present programme calls for a detailed study of intramolecular free radical ipso substitution reactions as a novel route to biaryls, heterobiaryls and styrene type units. These are often encountered in a wide variety of bioactive natural products of differing stucture and biosynthetic origin. The reactions developped will be used in natural product synthesis. The basic idea can be encapsulated in scheme 1 below.
Scheme 1 :
(1) Motherwell, W.B. Aldrichimica Acta 1992, 25(3), 71-80 and references 1-5 cited.

Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Topic(s)

• 0302 - Post-doctoral research training grants
• TC01 - Synthesis, New Molecules and Methods

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

UNIVERSITY COLLEGE LONDON

• EU contribution: No data
• Address: Gordon Street 20 Christopher Ingold Labs. ; WC1 0AJ LONDON ; United Kingdom
• Total cost: No data

Participants (1)

Not available

France

• EU contribution: No data
• Total cost: No data