Objective
Human T-lymphotropic virus type I and II (HTLV-I and -II) are retroviruses associated with neurologic degeneration and leukemia in a small part of infected individuals. HTLV-II is now spreading among intravenous drug users in Southern Europe, threatening the blood banks. The origin of these human retroviruses and the reasons for their observed genomic stability are not known. We have access to a unique African reservoir of endemic HTLV-II among Bambuti pygmies from Zaire. Sequencing this viral genome will allow us to investigate the origin of HTLV-II. The reverse transcriptase of this virus will be cloned and expressed to be able to investigate its fidelity as a possible reason for the extreme genetic stability of this retrovirus. Possibly, a reverse transcriptase with a high fidelity could result from this research, which could become a useful tool in molecular biology research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences genetics genomes viral genomes
- medical and health sciences clinical medicine oncology leukemia
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3000 LOUVAIN / LEUVEN
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.