Objective
It is proposed to investigate in detail the role of Ca2+ in transmitter release in a fast- transmitting CNS synapse by making simultaneous whole-cell recordings from a presynaptic terminal and its postsynaptic partner in a large axosomatic synapse in the medial nucleus of the trapezoid body. The Ca2+ concentration will be raised uniformly by flash photolysis of 'caged' calcium introduced in the presynaptic terminal via the patch pipette. The raise in Ca2+ will be quantified with a calcium-sensitive dye and calcium imaging techniques. The amount of
neurotransmitter that is released as a result of the increase in (Ca2+) will be quantified by measuring the currents in the voltage-clamped postsynaptic cell. By systematically varying the amount of UV exposure, an estimate of the relation between the presynaptic (Ca2+) and the transmitter output can be obtained.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69120 Heidelberg
Germany
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