Objective
Growth factors of the neuropeptide family ( bombesin, vasopressin, endothelin, bradykinin) stimulate DNA syntesis and proliferation in cultured cells and are implicated as growth factors in a variety of biological processes, including development, tissue regeneration and tumorigenesis. Recently, bombesin and other neuropeptides have been shown to stimulate a rapid increase in tyrosine phosphorylation of multiple substrates in 3T3 cells. Two of these proteins could be identified as p125FAK, a novel cytosolic tyrosine kinase with no typical SH2 and SH3 domains and paxillin, a cytoskeletal associated protein.
We plan to examine potential interactions between the SH2 domains of a variety of signalling and adaptor proteins with proteins which are tyrosine phosphorylated in response to neuropeptides. In particular, it is planned to define whether p125FAK and paxillin can form complexes with the SH2- domains of other signalling molecules ( p85alpha, Src, Crk, pl30CaS,Grb-2, Shc, Sos ) and whether paxillin is associated with p125FAK as a constitutive complex or if the complex is formed in response to ligands that stimulate tyrosine phosphorylation. This could clarify the signalling network involving cytoskeletal rearrangments, mitogenic phathways and cellular transformation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CM13 1LX London
United Kingdom
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