Objective
All forms of diabetes are characterized by hyperglycemia, development o diabetes-specific microvascular pathology and macrovascular complications. For example, as a consequence of the microvascular pathology, diabetes is now the leading cause of adult blindness. Until now, a clear understanding of the basic pathogenic mechanisms of diabetes has not yet emerged, but the generation of transgenic animal models may give the key to curing the disease.
Fatima Bosch's group has recently obtained transgenic mice that express IGF-I in pancreatic beta-cells. Preliminary results indicate that these animals are diabetic. In addition, these mice develop the long-term complications of the disease (cataracts, glaucoma, retinopathy). These mice constitute the first animal model that naturally develops ocular complications of diabetes mellitus.
In this project, using these transgenic mice, I will study the role of IGF-I in the pathogenesis of diabetes mellitus and the mechanisms leading to development of secondary complications. Furthermore, it has been described that IGF-II, like IGF-I, is able to suppress insulin release. I will obtain another transgenic animal model, overexpressing IGF-II in beta-cells, to study if this factor is also able to alter insulin secretion in vivo and lead to diabetic complications.
In conclusion these mice will be used to investigate the mechanisms leading to development of secondary complications and they will also be used to design new therapies to abolish the serious long-term complications of diabetes mellitus.
Fields of science (EuroSciVoc)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8193 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.