Objective
HPV gene expression relies tightly on its enhancer which in turn restri its activity to keratinocytes. In these permissive cells, viral expression is modulated by their differentiation status. The mechanisms that direct this selective transcriptional control have not been elucidated. We propose thus to characterise the structure, function, and regulation of the HPV 18 enhancer, and to identify the cellular transcription factors participating to its cell-type specificity. As AP-1 plays a central role in the enhancer activity, we will first look at the relative distribution of its different Jun/Fos members in a normal differentiating epithelium and compare it to a virally infected tissue. We will also examine the binding of these Jun/Fos heterodimers to the HPV 18 AP-1 site. We will next identify the unknown transcription factors that synergistically interact with the Jun/Fos complex, and study their expression in the epithelium and other tissues.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75724 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.