Objective
Peptide mimetics possess important advantages in comparison with naturally occurring and physiologically active peptides. Therefore we plan to synthesise pseudopeptides characterised by the replacement of the scissile peptide bond with the transition-state- analogous sulfonamido bond. As monomers we will prepare a large basic set of functionalized N-Boc protected vinylogous y-amino sulfonic acids, which are derived from naturally occurring amino acids like Ser. Asn, Trp etc. The next step will be the development of a solid phase synthesis of the vs-peptide bond using TentaGel-NH2 and a photocleavable linker moiety. This solid phase synthesis will enable us to construct combinatorial libraries containing vinylogous sulfonyl peptides. The screening of the libraries should permit the identification of new lead structures, which will be further optimised as new drugs. We are confident that new inhibitors of the aspartic proteases renin and HlV-protease will be found using this technology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- natural sciences chemical sciences organic chemistry amines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20133 MILANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.