Synthesis of sulfonamide pseudopetide combinatorial libraries

Project Information

Grant agreement ID: FMBI950328

Project closed

Start date 15 April 1996

End date 14 April 1998

Funded under

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Total cost No data

EU contribution No data

Coordinated by

THE UNIVERSITY OF MILANO
Italy

Objective

Peptide mimetics possess important advantages in comparison with naturally occurring and physiologically active peptides. Therefore we plan to synthesise pseudopeptides characterised by the replacement of the scissile peptide bond with the transition-state- analogous sulfonamido bond. As monomers we will prepare a large basic set of functionalized N-Boc protected vinylogous y-amino sulfonic acids, which are derived from naturally occurring amino acids like Ser. Asn, Trp etc. The next step will be the development of a solid phase synthesis of the vs-peptide bond using TentaGel-NH2 and a photocleavable linker moiety. This solid phase synthesis will enable us to construct combinatorial libraries containing vinylogous sulfonyl peptides. The screening of the libraries should permit the identification of new lead structures, which will be further optimised as new drugs. We are confident that new inhibitors of the aspartic proteases renin and HlV-protease will be found using this technology.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• natural sciences › biological sciences › biochemistry › biomolecules
• natural sciences › chemical sciences › organic chemistry › amines

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Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Topic(s)

• 0302 - Post-doctoral research training grants
• TC03 - Biological, Medicinal and Pharmaceutical Chemistry

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

THE UNIVERSITY OF MILANO

• EU contribution: No data
• Address: Via Venezian 21 ; 20133 MILANO ; Italy
• Total cost: No data

Participants (1)

Not available

Germany

• EU contribution: No data
• Total cost: No data