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New approaches towards the synthesis of c-glycosides

Objective



Saccharides in which the anomeric oxygen of the glycosidic bond is replaced by a carbon atom, the so-called 'C-glycosides', are an interesting class of carbohydrate antimetabolites. For instance, they are valuable tools in studying the role of carbohydrates in biological processes. Apart from this, they are possible enzyme inhibitors and a source of chiral synthons for the preparation of naturally occurring biomolecules. The main goal of this project is the development of a new, flexible methodology towards the stereoselective construction of C-glycosides, in which the two aldose are joined directly by carbon-carbon bonds. Therefore, we suggest an asymmetric hetero Diels-Alder approach for the construction of this class of C-glycosides.

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

UNIVERSITÀ DEGLI STUDI DI FERRARA
Address
Via Luigi Borsari 46
44100 Ferrara
Italy

Participants (1)

Not available
Netherlands