The aim of the present project is to elucidate the structure of secondary metabolites extracted from higher fungi, and to assay their biological activities.
Mushrooms are rich in secondary metabolites with unusual structures, some of which have already shown important pharmaceutical activities. Since only a few representatives of the mycological flora have been screened so far, we expect that more promising molecules will be found in the next years, and in fact the research efforts in this direction are multiplying worldwide.
A network of European collaborations will be utilised during the proposed project: the fungi will be grown in pure culture at the dept. of Biotechnology of the University of Kaiserslautern; the chemical characterization will be performed at Lund (mainly via advanced 2D NMR techniques); a fundamental pharmaceutical assay (binding to dopamine D 1 receptors) will be done at the Sct Hans Hospital in Roskilde, Denmark.