Extraction, isolation and structural characterization of metabolites from higher fungi. Assay of their biological and pharmaceutical activity

Objective

The aim of the present project is to elucidate the structure of secondary metabolites extracted from higher fungi, and to assay their biological activities.
Mushrooms are rich in secondary metabolites with unusual structures, some of which have already shown important pharmaceutical activities. Since only a few representatives of the mycological flora have been screened so far, we expect that more promising molecules will be found in the next years, and in fact the research efforts in this direction are multiplying worldwide.
A network of European collaborations will be utilised during the proposed project: the fungi will be grown in pure culture at the dept. of Biotechnology of the University of Kaiserslautern; the chemical characterization will be performed at Lund (mainly via advanced 2D NMR techniques); a fundamental pharmaceutical assay (binding to dopamine D 1 receptors) will be done at the Sct Hans Hospital in Roskilde, Denmark.

Fields of science

Programme(s)

FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Topic(s)

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

Lunds Universitet

Address

60,getingevagen
221 00 Lund
Sweden

Links

Participants (1)

Not available

Italy