Objective
Proteins are responsible of a very large number of biological functions in living systems. Among them enzymes are the catalysts in biological sytems. Their properties are strongly affected by their three-dimensional structure. Enzymes often contain transition metal ions which are involved in the reaction catalysed by the enzyme. The understanding of the functional behaviour of enzymes is linked to the knowledge of their three-dimensional structure.
There are different methods to analyse the structure of enzymes, by single crystal X-ray structure analysis or by multidimensional NMR techniques using the NOEs. The NMR analysis provides the structure of the proteins in a medium of biological interest, dissolved in water.
The NMR analysis normally only allows the characterization of small enzymes. In nature there are a lot of enzymes which contain paramagnetic transition metals in their active site. The paramagnetism of these enzymes, even if they are large, allows the study of the active site of these enzymes via the paramagnetic shift in their obtained NMR spectra. Targets of the project are the structural determinations of paramagnetic metalloproteins as cytochromes containing one or more iron atoms or at least to get a view of their active sites using multidimensional NMR techniques.
The change of the oxidation state of the transition metal atoms in the enzymes may cause differences in their solution structure which may be determined using these methods. So it should be possible to understand the functional behaviour of these redox active enzymes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences chemical sciences catalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
50121 Firenze
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.