Objective
CANCER IS A DISEASE CHARACTERIZED BY LOSS OF CELLULAR GROWTH CONTROL. AS SUCH, IT IS NOT SURPRISING THAT THE MOLECULAR MACHINERY OF THE CELL CYCLE IS INVOLVED IN TUMORIGENESIS. RECENT DISCOVERIES HAVE BROUGHT SEVERAL CELL-CYCLE REGULATORS INTO SHARP FOCUS AS FACTORS IN HUMAN CANCER. AMONG THE MOST CONSPICUOUS TYPES OF MOLECULE TO EMERGE FROM ONGOING STUDIES IN THIS FIELD ARE THE CYCLIN-DEPENDENT KINASE INHIBITORS SUCH AS p15 AND p16. THE EMPLOYMENT OF SUITABLE ANIMAL MODEL SYSTEMS WOULD GREATLY FACILITATE THE INVESTIGATION OF THESE GENES IN THE PRESENT PROJECT IT IS INTENDED TO USE THE MULTISTAGE SKIN CARCINOGENESIS MODEL BECAUSE THE STAGES OF INITIATION, PROMOTION AND PROGRESSION ARE WELL CHARACTERIZED. THE AIM IS TO ADOPT TWO COMPLEMENTARY APPROACHES. THE FIRST IS DESIGNED TO ANALYSE IN DETAIL THE GENETIC ALTERATIONS OF p15 AND p16 GENES. THIS ANALYSIS GIVES US THE OPPORTUNITY TO IDENTIFY THESE GENES AS TARGETS FOR THE ACTION OF CARCINOGENS.
THE SECOND IS BASED ON THE IDENTIFICATION OF FUNCTIONAL ALTERATIONS OF THESE GENES ASSOCIATED WITH SPECIFIC STAGES OF CARCINOGENESIS.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology
- social sciences economics and business business and management employment
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
G12 8QQ Glasgow
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.