Objective
The oncoprotein MDM2 and the tumour suppressor RB are important regulators of transcription factors (TFs): MDM2, for instance, inhibits the activity of p53, a TF that induces growth arrest or apoptosis upon DNA-damage, whereas RB inhibits - amongst others - the activity of E2F, a TF that promotes cell division. A precise control of these processes is a prerequisite for a reliable cell division with an intact genome. We found that MDM2 stimulates E2F and that RB interacts with p53. Therefore, it shall be investigated how MDM2 and RB regulate p53 and E2F, TFs with acidic activation domains, and how this affects cellular processes like growth control and apoptosis. Since we found that MDM2 can also interact with and activate the TF AP1, but not SP1, a TF with a glutamine rich activation domain, it shall be investigated, whether MDM2 is a general adaptor molecule of transcription.
Finally, a library screen using the yeast two hybrid system shall be carried out to identify further molecules interacting with and regulating the activation domain of E2F1.
The findings of this project should contribute to the understanding of the nature of cancer and to developing new drugs for treatment of various types of this disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1QR Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.