Objective
Chloride and anions transport in epithelial cells plays an extremely important role in equilibrium and omeostasis of solutes concentrations in an organism. Dysfunctions in anion transport systems are at the origin of several diseases
The project I propose to develop focuses on the characterization of the ionic channels performing chloride and anion transport on the basolateral membranes of a renal cultured cells line using the patch-clamp technique. I have recently developed a new technique allowing to overcome the intrinsic difficulty of access of basolateral membranes of cultured tissues to patch-clamp pipettes. This technique will allow the investigation of the characteristics of the ionic channels as well as of the intracellular mechanisms performing the control of their activity.
The results of the electrophysiological experiments, coupled with those obtained with other approaches developed in the host laboratory (in particular molecular biology) will offer a new insight into the physiology of transporting epithelia.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology
- natural sciences biological sciences molecular biology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
91191 Gif-sur-Yvette
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.