Objective
Undecylprodigiosin is a tri-pyrolle antibiotic made by Streptomyces coelicolor A3 (2). It is the major component (ca. 60%) of a mixture of four red pigments made by the strain, of which butylcycloheptylprodigiosin (ca.34%) is next most abundant compound. Genetic and feeding studies suggest that the compound is made via two convergent pathways, one responsible for production of bipyrollecarboxaldehyde, and the other the monopyrolle moiety. The latter has a fully saturated alkyl chain attached at position 2 of the pyrolle ring. Defined non-polar mutations will be made in each of three sequenced genes that are likely to play a role in mono-pyrolle production (redXWY), and the resulting mutants characterised: by cross-feeding and co-synthesis with previously isolated S. coelicolor red mutants and mutants of Serratia marcescens deficient in prodigiosin production; by analysis of the metabolites they produce; and by mutasynthesis using monopyrolle analogues.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NR4 7UH Norwich
United Kingdom
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