Objective
Our objectives are (1) to complete our identification of the biosynthetic origin of two TRH-like peptides which we first identified in human seminal fluid (2) to extend our knowledge of their physiological roles and (3) to identify factors involved in the regulation of their activity. The actions of pGlu Glu Pro amide are consistent with a role in fertility and we propose to study these two peptides in, and their action on, infertile males. The two peptides also exhibit central activities, some in common with benzodiazepines, and we will study these at the molecular level. During our studies of TRH-like peptides in the thyroid gland, we found that marmoset and human thyroid contain high concentrations of authentic TRH, together with a TRH-like peptide, suggesting a functional role for the thyroidal TRH. We also find that the levels of TRH in rat thyroid reflect the thyroid status; we intend to investigate the mechanisms involved. We are also developing a reliable method for the determination of TRH and TRH-like peptides in the circulation which will have clinical application.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- social sciences sociology demography fertility
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
30100 Murcia
Spain
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