Objective
The present project is intended to analyse, by using autoradiographic and molecular biology procedures, the state of the expression of beta-adrenoreptor subtypes (beta1 and beta2) in the human brain, under both normal and pathological (Alzheimer's disease) aging. For such purposes, autopsies brain samples for a number of individuals without history of neuropsychiatric disease, and from a group of Alzheimer's disease brains will be used. Autoradiographic labelling will be carried out with (125I) cyanopindolol and molecular expression of the receptors will be performed by using the baculovirus expression system. We will be comparing the levels of expression and the autoradiographic densities of beta-adrenoceptors in several critical regions (cortex, hippocampus, striatum, midbrain) to clarify 1) whether there is a defined pattern of changes along the different decades of life; and 2) the type of modification of brain beta-adrenoceptors in Alzheimer's disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- humanities history and archaeology history
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
39011 Santander
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.