Objective
Somatic hypermutation is, in part, responsible, for affinity maturation during an immune response. This process is highly regulated at both the cellular as well as at the molecular level. The frequency, distribution and nature of these mutations strongly suggest that the hypermutation process is not random. The underlying mechanism, however, has remained elusive.
Recently, lymphoid-specific enhancers have been shown to play a crucial rule in targetting the antibody V region (Betz et al., Cell 77, 239-248; Sharpe et al., EMBO J. 10, 2139-2145). Moreover, is has been demonstrated that the process exhibits specific base substitution preferences (Betz et al., PNAC, 90, 2385-2388) and is able to distinguish between the coding and noncoding strand. The aim of this project is to gain a better understanding of the regulation of the hypermutation machinery. For example, transgenic mice have been produced in Dr. Neuberger's laboratory to characterize the roles of enhancers. Using the above system I have already obtained interesting results (Nature, submitted). I will continue these studies as a PhD student starting October 1995.
The results will facilitate the establishing of an in vitro hypermutati system which could be used, for example, to produce mutant
non-immunoglobulin proteins in vivo.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- natural sciences biological sciences genetics mutation
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 2QH Cambridge
United Kingdom
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