Objective
The objectives of this proposed project is the elucidation of the metabolism and potential novel second messenger roles of the glycerophopshoinositol and lysophosphatidylinositol, the principle products that originate from phgosphoinositide-specific phospholipase a2 (pla2) activation. This enzyme has recently been characterised in thyroid cells and leads to the formation of these biologically active metabolites (Iacovelli et al, 1993; Corda et al, 1994; Falasca and Corda, 1994; Falasca et al, 1995). This should thus provide a further understanding of the proposed mechanisms of cross-talk between adenylylcyclase, PLA2 and the tyrosine kinases, particularly in the light of recent reports of both potentiating (Sevetson et al, 1993) and inhibitory (Wu et al, 1993) intercations between adenylylcyclase and the tyrosine kinases (Burgering et al, 1993; Cook and McCormick, 1993) that could be under feedback control via MAPK stimulation of PLA2 (Graves et al, 1993; Durstin et al, 1994), and hence via the production of glycerophosphoinositol 4-phosphate (Valitutti et al, 1991; Iacovelli et al, 1993).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
66030 Santa Maria Imbaro Chieti
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.