Objective
The specific aim of this proposal is to study the mechanisms by which regional and functional differences are established in the vertebrate forebrain during development. Using chick as a model, we will identify genetic fate determinants in the forebrain by examining the normal spatio-temporal expression of candidate genes. Possible new candidate genes such as vertebrate homologues of the drosophila distal-less homeobox gene (Dlx family), known to play a role in the specification of anterior segments, will be cloned using a PCR based approach. To study their role in forebrain patterning, we will use replication competent retroviral vectors to target over-expression of these genes in the developping chick brain. By analysing the effect these experiments have on the expression of specific markers, we will explore the hierarchy of genetic interactions that control the process of regionalisation in the forebrain.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SE1 9RT London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.