Objective
Catalysts increase the rate of chemical reactions without being consumed. Thus, small amounts of catalytically active species allow the preparation of large amounts of products. As far as carbon-carbon bond forming reactions are concerned, most of the established catalytic processes rely upon the use of nobel metals such as palladium, rhodium, ruthenium etc. Other transition metals which do not spontaneously regenerate a low-valent oxidation state after the desired C-C-bond formation cannot be used in a catalytic manner so far. This project tries to explore ways which allow to overcome this severe limitation.
Chlorosilanes as cheap, readily available and non-toxic
additives may pave the way. Specifically, studies on the titanium-mediated reductive coupling of carbonyl compounds to alkenes (McMurry synthesis) are proposed. A recently deviced procedure will be refined which has proved for the first time that this notoriously stoichiometric but highly useful transformation can in fact be rendered catalytic in titanium. Part of this project deals with the synthesis and evaluation of tailor-made ligands and with a detailed study of the actual nature of the intermediates involved in this catalytic process by spectro- scopic means. The insight gained during the course of this investigation will be applied to other transition metal induced reactions, which may also become catalytic when performed in the presence of an appropriate chlorosilane. The efforts will focus on those processes which hitherto require expensive and/or toxic metals in (over)stoichiometric amounts and which would become much more attractive for applications in natural product chemistry or for the synthesis of pharmacologically relevant targets if a catalytic alternative would exist.
Fields of science (EuroSciVoc)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
45470 MUELHEIM AN DER RUHR
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.