Objective
The general aim of the project is to study the cellular and molecular regulation of human adipose tissue HSL in physiology and pathology (obesity, metabolic syndrome), in relationship with the "in vivo" control of lipolysis. This will be achieved using "in vivo" and "in vitro" approaches. In the first part, lipolysis (in the basal state and its response to insulin catecholamines) and therefore HSL activity will be studied by microdialysis of abdominal and gluteal sub-cutaneous adipose tissue. For "in vitro" studies, isolated adipocytes will be obtained from biopsies of sub-cutaneous human adipose tissue from patients and control subjects. HSL response to insulin and A or B adrenergic agents will be measured and the expression of HSL will be determined. Moreover, we shall analyze sequences coding for HSL structure and study the regulation of its expression, looking for point mutations which could explain the effects in HSL function.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics mutation
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
17 176 SOLNA
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.