Objective
The secretory pathway of eukaryotic cells comprises several specialized membrane-bound compartments. Transfer of proteins between these compartments is mediated by transport vesicles. A correct targeting of these vesicles is accomplished by interactions between integral membrane proteins on the vesicles and target organelles, termed v-SNAREs and t-SNAREs, respectively. SNAREs required for anterograde transport from the endoplasmic reticulum (ER) towards the plasma membrane are already known. The discovery of a novel t-SNARE on the ER of yeast allows us to investigate for the first time the targeting of retrograde moving vesicles in the secretory pathway. Since both anterograde and retrograde v-SNAREs must be present on the same vesicles, either as targeting molecules or recycling passengers, it is possible that some of the vSNAREs involved in forward transport also have a role in retrograde traffic. The genetic and biochemical studies described in this proposal offer a unique opportunity to determine whether any of the known v-SNAREs act in this way or whether there is a separate set of retrograde vSNAREs to be discovered. Our investigations should contribute to a better understanding of how eukaryotic cells maintain their compartmental organization.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 2QH Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.