Objective
During mitosis of eucaryotic cells, the duplication and separation of the centrosome is crucial for proper chromosome segregation. I propose to characterize rosario, a Drosophila mitotic mutant identified in Pr. D. Glover's laboratory. Embryos laid by homozygous female for rosario fail to develop and show bipolar mitotic spindles nucleated by clusters of centrosomes. rosario mutants show centrosome separation defects without duplication failure, as well as chromatid separation defects at anaphase. I will determine whether the primary mitotic defect is in chromosome segregation or in centrosome separation, using real time observations. Furthermore, I will map the transcription units within an interval of 25kb of genomic DNA in which rosario lies and functionally identify rosario, by testing the ability of genomic fragments from this region to rescue the mutation following gerrn line transformation. Characterization of the rosario gene and its associated phenotype will help to understand relationships of the centrosome replication cycle to the process of chromosomes segregation.
Fields of science (EuroSciVoc)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DD1 4HN Dundee
United Kingdom
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