Objective
Glucose transport into cells is facilitated by a family of transmembrane proteins: glucose transporters (GLUTs). The aim of the project is to explore the hypothesis that during fetal development the synthesis and expression of GLUTs are regulated by thyroid hormones and that the shift in expression of the different isoforms in the neonatal period is dependent on synergism of thyroid hormones and insulin. Under pathophysiological conditions (changes in extracellular glucose, insulin, T4/T3 concentration) fetal and neonatal tissues will be obtained. Protein fractions, mRNA for GLUTs and other relevant genes will be isolated and their quantities and expression will be measured/analyzed using molecular biology techniques (Western/Northern blotting, RT-PCR, RNAse protection assays, in situ- and differential hybridization).
This project and training period will be an unique combination of expertise in molecular biology to be applied in follow-up projects with a physiological scope.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine obstetrics fetal medicine
- natural sciences biological sciences molecular biology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
28029 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.