Objective
Acidic fibroblast growth factor (aFGF) is a potent inducer of proliferation and differentiation of a variety of cells. The activity of the growth factor is partly transduced into the cells by activation of the specific FGF receptor tyrosine kinase, but an increasing amount of evidence indicates that translocation of the growth factor into the cells and to the nucleus is also required. In the host laboratory a novel method has been developed to test if the growth factor has gained access to the cytosol. By engineering a farnesylation signal onto the C-terminus of the growth factor, it is possible to monitor translocation into cells, since the farnesylation reaction occurs only in the cytosol and nucleus. Transport into cells depends on specific FGF receptors. A number of mutations of such a receptor (FGFR-4) has been made and their abilit,v to support endocytosis and transport to the cytosol and nucleus will be studied.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
0310 Oslo
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.