Objective
The regulated secretory process appears to be essential for the succes of Toxoplasma. as an intracellular parasite. Moreover, this parasite represents a very interesting model for secretion studies since three different regulated secretory organelles are found within one cell. This suggests that the secreted proteins have to be sorted toward the right organelle. We are now studying the targetting of the GRA proteins in the dense granules. we have identified in GRA proteins a conserved and specific peptide sequence. We presently test by transfection experiments of Toxoplasma the involvment of this sequence in targetting a reporter protein in the dense granules.
To study in more details the sorting process in Toxoplasma, we propose identify molecules which interact with GRA proteins. This work will be performed in the two-hybrid system in yeast. Four of the eight GRA genes that have been cloned in our laboratory will be used in yeast in the two-hybrid system (i) to study the possible interactions between GRA proteins themselves and (ii) to identify regulating proteins involved in their intracellular trafficking.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1640 Rhode-Saint-Genèse
Belgium
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