Objective Ethylnitrosourea-induced tumorigenesis of the rat nervous system provides a model for the molecular analysis of cell-type specific carcinogenesis. In the peripheral nervous system, a specific point mutation of the neu (ErbB-2) gene is critically associated with the initiation of malignant transformation in Schwann precursor cells. In rat brain, the RB13-6 monoclonal antibody recognizes a differentiation antigen transiently expressed by a subset of glial cells highly sensitive to ethylnitrosourea-transformation. The corresponding cell-surface antigen (gpl3RB13-6) is a glycoprotein related to the human and murine plasma cell glycoprotein PC-I. The cDNA and parts of the rat RB13-6 gene have been sequenced. In order to clarify the possible role of gp 130RB13-6 in the tumorigenic process, this project includes: (a) mapping and functional analysis of the 5 regulatory region of the RB13-6 gene; (b) mutation analysis of this gene; and (c) study of the phenotypic changes in cells expressing wild-type or mutant RB13-6 transgenes. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesgeneticsmutationnatural sciencesmathematicspure mathematicsmathematical analysisfunctional analysis Programme(s) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Topic(s) 0302 - Post-doctoral research training grants TL07 - Immunology and Cancer Call for proposal Data not available Funding Scheme RGI - Research grants (individual fellowships) Coordinator Universität Gesamthochschule Essen EU contribution No data Address Hufelandstraße 55 45147 Essen Germany See on map Total cost No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all Not available France EU contribution No data Address See on map Total cost No data