Objective
Visceral leishmaniasis (VL) caused by the protozoan parasites L. donovani and L. infantum (L. chagasi) is a potentially fatal disease with a major impact on health in the developing countries For many years however, a dramatic increase in the number of leishmanial infections in HIV positive patients from endemic areas has been noted along with cases refractory to curren antimonial chemotherapy. As an intact immunological system is necessary for drug therapy to b effective, studies concerning the nature of the interaction between drugs and the immune responsz are of paramount importance. The main objectives of our proposal are 1r) to assess the nature of the immune response occuring during chemotherapy for VL in a murine model, concentrating on interleukines (IL) 6 and 10 witl known macrophage de-activating effects, 2r) to study the pathogenesis of VL in IL-6 deficient mice and 3r) to evaluate the consequences of immune modulation such as cytokine neutralisation (IL-6 and/or IL- 10) for effective chemotherapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1E 7HT London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.