Objective
The induction of protective immunity relies on immunological memory i.e. the ability of the immune system to respond more efficiently to a secondary antigenic chalenge. The capacity to recognize previously encountered antigens is retained over long periods and affects B and T lymphocyte populations. In this study, mice expressing a transgenic TCR which recognizes a peptide from influenza virus nucleoprotein presented on H-2 ClassI Db molecules will be used to study phenotypic and functional properties of memory CD8+ cytotoxic T cells. To follow activated CD8+ T cells over long periods,we will establish a method of labelling cells in vivo with a replication defective retrovirus which carries a B-Gal reporter gene. Phenotypic characterisation will include expression of membrane molecules which could be involved in long term survival of memory CD8 T cells. Functional analysis will be focussed on TCR signalling (regulation of intracellular calcium levels and activation of tyrosine kinases) as well as antigen dependant cytolytic activity and proliferation. To identify the mechanisms responsible for long term survival of memory CD8 T cells, expression of bc1-2 family survival genes as well as cytokine genes will be investigated.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences health sciences infectious diseases RNA viruses influenza
- medical and health sciences basic medicine immunology
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69364 Lyon
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.