Objective
Biochemistry and Signalling Mechanism(s) of Imidazoline Receptors Imidazoline receptors are known to be implicated in several pathologies such as hypertension, depression and diabetes mellitus. Pharmacologically, they can be devided in at least two subgroups: I1 and I2 receptors. The blood pressure lowering potencies of a series of imidazolines corresponds to the pharmacological profile of the I1, not the I2 receptor type. Therefore it is of major interest to know the functional mechanism of central I2 receptors of which, in contrast to I2 receptors, little is known. To gain more insight we propose to determine the subcellular localization of these receptors and what their signalling pathway(s) can be. Subsequent purification and biochemical studies of the receptor molecule itself can inform us about its cellular effects and give an experimental basis for future determination of cDNA sequences and genetic studies. The results can provide new information to aid the design of newer generations of specific drugs for multiple diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
67000 Strasbourg
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.