Objective
Considerable evidence suggests that the E2F transcription factor family play a critical role in cell growth control. Study of E2F1 protein, a major component of E2F has shown that its activation domain could be repressed by direct binding of the retinoblastoma protein and activated by binding of the proteins MDM2 and CBP to this same domain. The same region of the activation domain of E2F1 is bound by RB and CBP, which display antagonistic effect on E2F1 activity. The aim of this project will be to establish the relationship between RB and CBP interaction at the E2F1 activation domain. This will include a biochemical analysis in order to characterize the mechanism of RB and CBP binding to the E2F1 activation domain. It will also include a biological analysis, in order to establish whether CBP, through the activation of E2F1, can overcome the RB-induced G1 arrest, induce S-phase progression or display oncogenic activity in cooperation with an activated ras oncogene.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1QR Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.