Objective
Transplantation of neural tissues in the central nervous system is widely used to pursue neurobiological issues concerning the normal and pathological brain. Recent developments have opened up the possibilities of grafting primary precursor cells cultured in vitro instead of fetal brain tissues. In that way E10 neural tube of transgenic mice bearing thermolabile TAg of SV40 virus will be dissected in order to isolate new multipotential immortalised neuroepithelial cell lines. These cell lines will be characterised at non permissive temperature using immunocytochemical and nucleic markers for neurons and glia. Selected lines will be transfected with Lac Z reporter gene and microtransplanted into various brain regions. Then the survival, the fate of grafted cells and their capability to restore cognitive function of ischaernied rat will be studied. In addition to provide cell lines of readily expandable cells optimal for recovery of cognitive function, these transplantable cells would be excellent tools to study differentiation, cell plasticity and to introduce in brain exogenous gene.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology cognitive neuroscience
- natural sciences biological sciences microbiology virology
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Coordinator
54006 Thessaloniki
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.