Objective
Diabetes mellitus is the most common metabolic disease in humans. All forms of diabetes, both inherited and acquired, are characterized by hyperglycemia, an absolute or relative lack in insulin, and development of diabetes specific microvascular pathology in the retina and renal glomerulus, neurological complications and macrovascular complications. Fatima Bosch's group has developed three transgenic animals models expressing PEPCK/glucokinase, PEPCK/myc and PEPCK/insulin chimeric genes respectively, at hepatic level. These animals remain normoglycemic despite a destruction of B cells, suggesting that engineering extrapancreatic tissue to express these genes during diabetes might be an useful approach of gene therapy for diabetes.
This project is focused on the use of these three chimeric genes for the establishment of new therapeutical approaches of diabetes. In conclusion, this study will provide informations about the feasibility of the gene therapy in human diabetic patient.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciencesmedical biotechnologygenetic engineeringgene therapy
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicineophthalmology
- medical and health sciencesbasic medicinepathology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Call for proposal
Data not availableFunding Scheme
RGI - Research grants (individual fellowships)Coordinator
08193 Barcelona
Spain