Regulation of splicing by protein phosphorylation

Project Information

Grant agreement ID: FMBI960882

Project closed

Start date 1 August 1996

End date 31 July 1998

Funded under

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Total cost No data

EU contribution No data

Coordinated by

UNIVERSITY OF DUNDEE
United Kingdom

Objective

The aim of our studies will be to elucidate the mechanism and role of reversible protein phosphorylation in the regulation of pre-mRNA splicing. Recently it was shown that protein dephosphorylation plays an important role in the pre-mRNA splicing process. Phosphorylation mechanisms can be regulated either through activities of protein kinases, which add phosphates, or via protein phosphatases which remove them, or both Since considerable evidence points for a role of protein phosphatases affecting pre-mRNA splicing, we propose to identify and characterise native forms of nuclear protein phosphatases acting on splicing factors. We will be using a newly developed affinity chromatography method in order to punfy and characterise native nuclear phosphatases acting on splicing factors.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules › proteins

Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Topic(s)

• 0302 - Post-doctoral research training grants
• TL02 - Molecular Biology and Biochemistry

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

UNIVERSITY OF DUNDEE

• EU contribution: No data
• Address: MSI/WTB Complex Dow Street ; DD1 4HN DUNDEE ; United Kingdom
• Total cost: No data

Participants (1)

Not available

Sweden

• EU contribution: No data
• Total cost: No data