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Regulation of splicing by protein phosphorylation

Objective



The aim of our studies will be to elucidate the mechanism and role of reversible protein phosphorylation in the regulation of pre-mRNA splicing. Recently it was shown that protein dephosphorylation plays an important role in the pre-mRNA splicing process. Phosphorylation mechanisms can be regulated either through activities of protein kinases, which add phosphates, or via protein phosphatases which remove them, or both Since considerable evidence points for a role of protein phosphatases affecting pre-mRNA splicing, we propose to identify and characterise native forms of nuclear protein phosphatases acting on splicing factors. We will be using a newly developed affinity chromatography method in order to punfy and characterise native nuclear phosphatases acting on splicing factors.

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

UNIVERSITY OF DUNDEE
Address
Msi/wtb Complex Dow Street
DD1 4HN Dundee
United Kingdom

Participants (1)

Not available
Sweden