Objective
The aim of our studies will be to elucidate the mechanism and role of reversible protein phosphorylation in the regulation of pre-mRNA splicing. Recently it was shown that protein dephosphorylation plays an important role in the pre-mRNA splicing process. Phosphorylation mechanisms can be regulated either through activities of protein kinases, which add phosphates, or via protein phosphatases which remove them, or both Since considerable evidence points for a role of protein phosphatases affecting pre-mRNA splicing, we propose to identify and characterise native forms of nuclear protein phosphatases acting on splicing factors. We will be using a newly developed affinity chromatography method in order to punfy and characterise native nuclear phosphatases acting on splicing factors.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DD1 4HN DUNDEE
United Kingdom
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