Objective Changes in gene expression is one mechanism by which neurons transform short-lasting electrical events into long-lasting adaptive changes that may underlie learning and memory. Calcium (Ca2+) influx through the N-methyl-D-aspartate (NMDA) subtype o glutamate receptors and L-Type Ca2+-channels is the trigger for electrical activity-dependent transcriptional responses. To analyse the mechanisms controlling Ca2+-activated transcription, we are using the c-fos gene as a model system. Analyses of the c-fos promoter lead to the identification of Ca2+ -responsive DNA regulatory elements. However, additional as yet unidentified control regions that lie within the transcribed region of the c-fos gene are necessary for Ca2+-dependent transcriptional activation Aim of this proposal is the identification and characterisation of intragenic Ca2+ control elements. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural scienceschemical sciencesinorganic chemistryalkaline earth metals Programme(s) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Topic(s) 0302 - Post-doctoral research training grants TL02 - Molecular Biology and Biochemistry Call for proposal Data not available Funding Scheme RGI - Research grants (individual fellowships) Coordinator MRC Unit of Molecular Neurobiology Address Hills road CB2 2QH Cambridge United Kingdom See on map EU contribution No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all Not available Germany EU contribution € 0,00 Address See on map Other funding No data
