Objective
Corticotropic-releasing factor (CRF) is a neuropeptide that displays a variety of effects in the nervous system. CRF is the primary physiological mediator of stress responses and stressinduced disorders in the brain. The effects of acute stress are mediated in part by neurons of the locus coeruleus (LC), a nucleus containing 50% of the brain's norepinephrine neurons. Chronic stress increases the firing rate of LC neurons and increases levels of norepinephrine in this nucleus, indicating that CRF mediates the biochemical adaptive response of LC noradrenergic neurons to chronic stress. CRF induces short- and long-term changes in the physiology of neurons. Long-term effects of CRF requires changes in the expression of genes. It has been recently observed by us that CRF is able to alter gene expression using the cAMP signaling pathway.
This research project is addressed to identify genes induced following application of CRF in an anterior pituitary cell line as well as in an immortalized LC neuronal cell line using the differential display technique.
The identification of CRF-responsive genes may be important in elucidating mechanisms by which stress triggers and sustains the biochemical alterations associated with stress-related disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine physiology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
70124 Bari
Italy
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