Optimisation of proton-electron double-resonance imaging and electron paramagnetic resonance imaging for in vivo detection of free radicals

Informations projet

N° de convention de subvention: FMBI960973

Date de début

Date de fin

Financé au titre de

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Coût total € 0,00

Contribution de l’UE Aucune donnée

Coordonné par

UNIVERSITY OF ABERDEEN
United Kingdom

Objectif

This project is concerned with the development and optimisation of proton-electron double-resonance imaging (PEDRI), a technique which combines magnetic resonance imaging (MRI) with electron paramagnetic resonance (EPR) in order to image the distribution of free radicals in biological samples and in living animals. The project will explore the use of advanced radiofrequency EPR techniques in order to improve the sensitivity of PEDRI. In particular, the use of ultra-fast pulsed EPR irradiation will be investigated, since it offers a theoretical two-fold sensitivity advantage over continuous-wave EPR irradiation. Multi-tuned resonators for PEDRI will also be developed in combination with automatic frequency/matching controls to improve efficiency. Detailed comparisons between the different irradiation strategies will be made under a variety of experimental conditions, and optimum parameters for the use of these techniques to study free radicals in vivo will be determined.

Champ scientifique

• engineering and technology › electrical engineering, electronic engineering, information engineering › information engineering › telecommunications › radio technology › radio frequency
• engineering and technology › medical engineering › diagnostic imaging › magnetic resonance imaging

Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Thème(s)

• 0302 - Post-doctoral research training grants
• TP15 - Instrumentation and Applied Physics

Appel à propositions

Data not available

Régime de financement

RGI - Research grants (individual fellowships)

Coordinateur

UNIVERSITY OF ABERDEEN

• Contribution de l’UE: Aucune donnée
• Adresse: Foresterhill ; AB25 2ZD ABERDEEN ; Royaume-Uni
• Coût total: Aucune donnée

Participants (1)

Not available

Italie

• Contribution de l’UE: Aucune donnée
• Coût total: Aucune donnée