Objective
AR 28 klDa protein of Brucella has been shown to induce antibody response in infected sheep not detected in vaccinated animals. This makes this protein an interesting candidate for a brucellosis diagnostic test ailowing the differentiation between infected and vaccinated animals something difficult with the current serological tests usually detecting anti-LPS antibodies that are generated in both infected and vaccinated animals. These antibodies are also responsible for cross-reactions with other microorganisms . The objectives are:
- To evaluate the interest of the recombinant protein for the specific diagnosis of brucellosis and serological differentiation between infection and vaccination in sheep and cow.
- Construction of vaccinal mutant strains not expressing the protein. Vaccination with these mutants would improve the test effectiveness avoiding the detection of possible positive reactions among vaccinated animals.
- To analyze, using the mouse model, the role of the protein in the protective activity and virulence of the vaccinal strains.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencesbiological sciencesmicrobiology
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Call for proposal
Data not availableFunding Scheme
RGI - Research grants (individual fellowships)Coordinator
37007 SALAMANCA
Spain