Objective
There are three pharmacologically characterised groups of metabotropic glutamate receptor (mGluR). Two of these are reported to inhibit and one to enhance glutamate release presynaptically. The host group has a well established project on presynaptic neurotransmitter release evoked by ionotropic glutamate receptor (iGluR) agonists.
The project aims to characterise mGluR modulated neurotransmitter release in the cerebral cortex, in vitro and in vivo. An emphasis will be the modulation of iGluR mediated release.
The work programme will staxt by using the synaptosomal model and then proceed to test the effects found using microdialysis. Pilot studies have shown that both parts are possible.
There are few studies which have detailed the pharmacology of mGluR modulateded release and none which address mGluR modulation of iGluR-mediated release.
The study will be aided by the provision of some novel materials from industry.
If sucessfull this project will provide the basis for further transnational European collaborations.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3049 Coimbra
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.