Objective
Plants have constitutive resistance to infection by several fungi due to the presence of saponins (glycosylated steroidal or triterpenoid compounds) in the cells. Several fungi have developed a way to overcome this resistance by expressing an enzyme able to break down the corresponding saponin.
Avenacin A1 and oc-tomatin are two saponins which can be hydrolysed by the enzymes avenacinase and tomatinase, respectively, which are produced by plant pathogenic fungi. Using a phage displaying antibodies library, I will isolate antibodies against these two enzymes able to block their action. I will use the genes encoding these antibodies to transform oat and tomato embryogenic cells to produce transgenic plants resistant to their infecting fungi that can also be used to study more precisely the mechanisms of resistance. To improve the understanding of these mechanisms, I will also generate antibodies against oc-tomatine that can serve for the screening of mutant plants after mutagenesis to obtain tomatin-deficient mutants.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences microbiology mycology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds cereals
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NR4 7UH NORWICH
United Kingdom
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