Objective
Bovine and human respiratory syncytial virus (BRSV/HRSV) are antigenetically related and are a major cause of severe lower respiratory tract disease in young children or calves. Infection of calves with BRSV results in considerable economic loss. Previous studies in calves have highlighted the importance of antibody and CD8+T-cell in recovery from and immunity to RSV infection. Dendritic cells are the most potent antigen presenting cells (APC) and may play an important role in presenting viral protein to T-cells in the respiratory tract following infection as well as systemically following vaccination.
The objective of the proposed project is to compare combinations of dendritic cells from blood and subsets from afferent lymph with monocytes and B cells as APC using whole RSV or viral proteins in vitro and in vivo. Cytokines produced by responding T cells will be analysed to determine whether the APC or viral polypeptides preferentially induce a TH1 or TH2 response. The proposed large animal model can be used to investigate aspects of the interaction of APC and T-cells that are not possible in humans. Finally, the results may help to establish new strategy in vaccination against BRSV targeting dendritic cells as the priming APC.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
RG16 0NN Newbury
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.