Objective
Peroxisome proliferator-activated receptor (PPAR) binds to specific DNA sequences and thereby activates gene transcription.
The aim of this project is the understanding of molecular mechanisms of gene regulation by PPAR. The PPAR mediated gene activation, which has been studied in the host institute intensively, serves as a suitable model to understand general principles in gene regulation.
In the host group different PPAR interacting proteins have been identified. These are the basis for different approaches to reveal PPAR mediated gene activation.
Full-length cDNA of still identified PPAR interacting proteins will be obtained by phage screening and their biological role will be characterized in cell culture DNA-transfection experiments.
To identify their interacting partners, proposing PPAR interacting factors will be used in vivo in a yeast two hybrid system and in a new in vitro system, which has to be adapted for phage screening.
Positive interacting factors will be analysed in an in vitro transcription assay and in cell culture and thereby, the general validity of PPAR mediated gene regulation for other hormone receptors will be tested.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
141 86 Huddinge
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.