Objective
The erbB family of receptors includes four members, whose prototype is the epidermal growth factor receptor. In contrast to the EGF receptor, the physiological roles of other members of the family are not clear. However, the erbB2 receptor, whose mutation induces neoplastic transformation, may act as a co-receptor in the signalling of other erbB members. Specifically, deletion of the erbB2 allele in transgenic mice leads to embryonal death at E10.5 resulting from major defects in development of the heart and peripheral nervous system.
In order to establish the basis of erbB2 function, especially its role in later development, a twin strategy employing conditional gene ablation and cell lineage analysis is proposed. This will enable the elucidation of the functions of erbB2 in the development and maintenance of the peripheral nervous system, of epithelia, and in oncogenesis. Additional experiments will focus on the biochemical characterisation of this important receptor.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences genetics mutation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
13125 Berlin
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.