Study of biointeractions at functionalised polymeric surfaces

Project Information

Grant agreement ID: FMBI961158

Project closed

Start date 1 November 1996

End date 31 October 1997

Funded under

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Total cost No data

EU contribution No data

Coordinated by

University of Nottingham
United Kingdom

Objective

"STUDY OF BIOINTERACTIONS AT FUNCTIONALISED POLYMERIC SURFACES" This project aims to characterise the surface properties of functionalised polysaccharides deposited on a gold surface. Polysaccharides of varying molecular weight will be substituted with thiol side groups able to bind covalently onto gold surfaces. The polymers can be substituted with additional functional pending groups such as poly(amido-amines)s which possibly interact with biological polymers e.g. proteines or polysaccharides (heparine).
Furthermore, this programme not only includes the development of new approaches for the immobilisation of biomolecules at polymeric interfaces but also the detailed study of their interactions with other biomolecules such as blood components, at the molecular level.
In a next step, it is obvious that the information obtained will be employed to improve the design of advanced biomaterials (e. g. implants) and the development and/or optimisation of biosensors.
The physico-chemical analysis of the polysacchalide coatings and their interactions with biopolymers will be studied by a wide range of surface characterisation techniques such as SIMS, XPS, AFM, elipsometry and surface plasmon resonance.

Fields of science

• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors › biosensors
• natural sciences › chemical sciences › polymer sciences
• engineering and technology › materials engineering › coating and films
• natural sciences › biological sciences › biochemistry › biomolecules › carbohydrates
• engineering and technology › industrial biotechnology › biomaterials

Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Topic(s)

• 0302 - Post-doctoral research training grants
• TC06 - Surface Science, Colloids & Heterogenous Catalysis

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

University of Nottingham

• EU contribution: No data
• Address: University Park ; NG7 2RD Nottingham ; United Kingdom
• Total cost: No data

Participants (1)

Not available

Belgium

• EU contribution: No data
• Total cost: No data