Objective
(2:2) Paracyclophane (2.2.PCs) are systems in which the benzene rings are held closely, face to face so that independent rotation of either ring is impossible. Consequently all mono- and many poly-substituted 2.2.PCs are linearly chiral. Because the systems are chemically and chirally very stable they are ideal as substrates on which to design chiral reagents, auxiliaries and catalysts and for incorporation into otherwise non-chiral moieties.
One result of our studies is the production of unique homochiral 2.2PC aminoacids. The project will build on this as follows:
(i) Improved synthesis of all possible 2.2PC amino-acids will be sought. (ii) The amino-acids will be incorporated into linear and cyclic peptides, so affecting their topology and lipophilicity.
(iii) The corresponding amino-alcohols lactams and related compounds will be investigated as chiral catalysts for metal catalysed reactions (eg Michael Reactions) and as chiral auxiliaries for a wide variety of reactions such as carbanion reactions, Diels-Alder and Michael reactions.
Fields of science (EuroSciVoc)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SA2 8PP SWANSEA
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.