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Challenges in asymmetric sonochemistry


The objective of this project is to extend the application domain of ultrasound from its present use in classical organic reactions to the field of asymmetric synthesis and transitional metal mediated synthesis. In the latter case sonication could be the answer to problems concerning moderate yields, high temperatures and long reaction times. The use of combinatorial technologies combined with ultrasound will provide new methods of forming C-C bonds in an efficient manner. For the sonochemically assisted asymmetric synthesis we will focus on the use of a novel B-amino alcohol template as the source of chirality. In both fields we anticipate that the ultrasound conditions will have a profound influence, not only on reaction rates and chemical yields, but also on the observed regio- and stereoselectivities.

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SmithKline Beecham Pharmaceuticals Ltd.
Great West Road
TW8 9EP Brentford
United Kingdom

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