Objective
The main aim of this project is to elucidate the molecular mechanism by which insulin regulates the synthesis of glycogen and other biosynthetic processes in mammalian skeletal muscle.
It is well known that defects in the regulation of glycogen synthase (GS) by insulin contribute to the insulin resistence observed in NIDDM patiens, obesity, hypertension and IDDM. The activation of GS by insulin is achieved through the inhibition of GS Kinase 3 (GSK3). Recents evidences showed that this inhibition is caused in vivo by its phosphorylation by the protein kinase c-Akt. In its turn, c-Akt is activated by phosphorylation in response to insulin. Recent experiments in the MRC Protein phosphorylation Unit have identified a novel insulin-stimulated protein kinase which phosphorylates a synthetic peptide corresponding to one region of the c-Akt protein.
The objective of the project is to characterise the protein kinase(s) and phosphatase(s) responsible for the catalysis of the
phospho-dephosphorilation of c-Akt and to discover how it is activated by insulin. The elucidation of this important insulin signal transduction pathway may contribute to the development of treatments of diabetes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences chemical sciences catalysis
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DD1 4HN Dundee
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.